Warning: Contains spoilers for Yotsuba&! chapter #114.Azumanga Daioh, one of the best anime from the 2000s, is officially back, and it returned in a way no one expected. Azumanga Daioh is an iconic comedy anime from the 2000s that’s often seen as the series that built the foundations of the “cute girls doing cute things” genre, and even after over 20 years, the series is still held in high regard by fans and critics alike.