The following contains spoilers for 28 Years Later, now playing in theaters28 Years Later has a huge twist involving the birth of a human girl, which teases some big changes about the Infected and could impact the future of the franchise. The long-awaited third film set in the 28 Days Later universe, 28 Years Later returns with a new cast of central characters. Introduced living their lives in a remote village somewhat removed from the mainland, people like Spike, Isla, and Jamie have been able to carve out good lives for themselves while doing their best to avoid run-ins with the Infected.